Dozens to be deliberately infected with coronavirus in UK ‘human challenge’ trials

The challenge trials aim to accelerate the development of COVID-19 vaccines. Credit: Nature – Andrey Rudakov/Bloomberg/Getty

Young, healthy people will be intentionally exposed to the virus responsible for COVID-19 in a first-of-its kind ‘human challenge trial’, the UK government and a company that runs such studies announced on 20 October. The experiment, set to begin in January in a London hospital if it receives final regulatory and ethical approval, aims to accelerate the development of vaccines that could end the pandemic.

Human challenge trials have a history of providing insight into diseases such as malaria and influenza. The UK trial will try to identify a suitable dose of the SARS-CoV-2 virus that could be used in future vaccine trials. But the prospect of deliberately infecting people — even those at low risk of severe disease — with SARS-CoV-2, a deadly pathogen that has few proven treatments, is uncharted medical and bioethical territory.

Proponents of COVID-19 challenge trials have argued that they can be run safely and ethically, and that their potential to quickly identify effective vaccines outweighs the low risks to participants. But others have raised questions about the safety and value of these studies, pointing out that large-scale efficacy trials involving tens of thousands of people are expected to deliver results on several COVID-19 vaccines soon.

Read the Article in Nature

Interested in learning more about and volunteering for Human Challenge Trials for COVID-19 vaccines?

COVID-19 Human Challenge Trials
Dozens to be deliberately infected with coronavirus in UK ‘human challenge’ trials
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