Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

In findings published in Science last week, Researchers from the University of Washington, the Institute Pasteur in Paris, and Vir Biotechnology in Switzerland have developed an ultrapotent cocktail of antibodies from recovered COVID-19 patients has been shown to recognize and lock down the infection machinery of the pandemic coronavirus and keep it from entering cells. Each of the antibody types performs these overlapping tasks slightly differently.  
In addition to preventing virus entry into host cells, the presence of the antibodies also seems to set off the infection-fighting actions of other immune cells, which arrive to clear out the virus.

“We believe that leveraging multiple, distinct, complementary mechanisms of action could provide additional benefits for clinical applications,” the researchers noted. “Our results pave the way to implement antibody cocktails for prophylaxis or therapy that might have the advantage of circumventing or limiting the emergence of viral escape mutants,” the researchers noted. The antibody cocktail in their study needs to undergo trials in humans to determine safety and effectiveness.

More Reading on Science Daily: Ultrapotent antibody mix blocks COVID-19 virus attachment

Read the Article: Science 24 Sep 2020

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
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